Fibrinogen Replacement: A Questionable Dogma

Authors: Duque, P; Korte, W

Affiliations: Department of Anesthesiology and Intensive Care, Gregorio Marañon Hospital, Madrid, Spain. Haemostasis and Haemophilia Center, St. Gallen, Switzerland.

Publication: HAMOSTASEOLOGIE; 2025

ABSTRACT: Management of hemostasis in the perioperative setting, in trauma or in acute care, has considerably changed over the last two decades. Viscoelastic testing and single-factor replacement therapies have become cornerstones of the respective clinical approaches. Here, we illuminate the basic theories for these approaches as well as the important evidence available. Both viscoelastic assays and single-factor replacements are important improvements; their use must be based on the strongest scientific evidence available.